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Links

 

Biomedical Applications of PNAs:

PANAGENE (South Korea)

NeuBase Therapeutics (Pittsburgh, USA)

Trucode Gene Repair (California, USA)

PolyOrg (Massachusetts, USA)

Creative Peptides (NY, USA)

PNA Bio (USA)

OpGen (USA)

Agilent (USA)

Eurogentec (Belgium)

ASM Research Chemicals (Hannover, Germany)

Alpha Laboratories (UK)

Link Technologies (UK)

浙江省宁波市康贝生化有限公司 KangBeiBio (Zhejiang, PR China): PNA synthesis

北京赛百盛基因技术有限公司 SBS Genetech (Beijing, PR China): PNA synthesis

北京旌准医疗科技有限公司 GenomePrecision (Beijing, PR China): PNA probes

上海科肽生物科技有限公司 Scipeptide (Shanghai, PR China): PNA synthesis

成都川抗派德生物医药科技有限公司 CP Biochem (Chengdu, PR China)

Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids

(Email: RNA-CHEN<at>outlook.com)

Collaborators:

Prof. Kung-Yao CHANG Group,  National Chung Hsing University

Prof. Leilei CHEN,  CSI/NUS

Prof. Yonggui CHI,  SPMS/NTU

Dr. Mei Sian CHONG,  Tan Tock Seng Hospital

Prof. Jean-Luc DECOUT, University Grenoble Alpes-Joseph Fourier, France

Prof. Yonggui GAO,  SBS/NTU

Prof. Cheng KAO,  Indiana University, USA
Prof. Ela KIERZEK,  Polish Academy of Sciences, Poland
Prof. Ryszard KIERZEK,  Polish Academy of Sciences, Poland
Prof. Tianhu LI,  SPMS/NTU

Prof. Ding Xiang LIU,  SBS/NTU
Prof. Xuewei LIU,  SPMS/NTU

Prof. Teck-Peng LOH,  SPMS/NTU

Prof. Lanyuan LU, SBS/NTU

Dr. Yunpeng LU,  SPMS/NTU

Prof. Dahai LUO,  LKCMedicine/NTU

Dr. David LYE Chien Boon,  Tan Tock Seng Hospital

Souvik MAITI, CSIR-Institute of Genomics and Integrative Biology, India

Dr. Oon Tek NG,  Tan Tock Seng Hospital

René Olsthoorn, Leiden University, Netherland

Prof. Konstantin PERVUSHIN,  SBS/NTU
Prof. Anh Tuan PHAN,  SPMS/NTU

Dr. Mookkan PRABAKARAN, Temasek Life Sciences Laboratory

Prof. Xavier ROCA,  SBS/NTU

Prof. Prabha SAMPATH, IMB, A*STAR

Prof. Yong SHAO,  Zhejiang Normal University
Prof. Susana GEIFMAN-SHOCHAT,  SBS/NTU

Dr. Steve SMITH,  Steve Smith Engineering, USA

Prof. Richard SUGRUE,  SBS/NTU

Prof. Sek-Man WONG,  NUS

Prof. Bengang XING,  SPMS/NTU

Prof. Qihua XIONG,  SPMS/NTU

Prof. Danzhou YANG,  Purdue Univ

Dr. Lishan YAO,  Chinese Academy of Sciences
Prof. Edwin YEOW,  SPMS/NTU

Prof. Dawei ZHANG,  SPMS/NTU

Prof. Yanli ZHAO,  SPMS/NTU

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Presentations

  1. Dec 2020, Invited speaker for the symposium of Functional Nucleic Acids: Chemistry, Biology, and Materials Applications (organized by Scott Silverman, Maria DeRosa, Zhen Huang, Yingfu Li, Yi Lu, and Hiroaki Suga) at Pacifichem 2020, jointly sponsored by seven Pacific Basin chemical societies (http://www.pacifichem.org). (Honolulu, Hawaii, December 15-20, 2020)

  2. Jan 2020, Seminar, National Taiwan University, Taiwan

  3. Jan 2020, Seminar, Nanjing Agricultural University, Nanjing, PR China

  4. Dec 2019, Seminar, Zhejiang University of Technology, Hangzhou, PR China

  5. Dec 2019, Keynote presentation, The 5th Conference on Advances in Biochemistry and Molecular Biology (CABMB 2019), Sanya, PR China

  6. Nov 2019, Contributed presentation, The 11th Chinese National Conference on Chemical Biology, Guangzhou, PR China

  7. Nov 2019, Seminar, South China Agricultural University, Guangzhou, PR China

  8. Nov 2019, Invited presentation. The 7th China Nucleic Acids Forum, Guangzhou, PR China

  9. Nov 2019, Seminar, School of Physics, Sun Yat-sen University (SYSU), Guangzhou, PR China

  10. Sep 2019, Seminar, Shenzhen Bay Laboratory, Shenzhen, PR China

  11. Jul 2019, Invited presentation. The 2nd East Asian Symposium on Single-Molecule Biological Sciences, Seoul National University, Seoul, Republic of Korea

  12. Jul 2019, Seminar, School of Medicine, SUSTech, Shenzhen, PR China

  13. May 2019, Seminar, School of Life and Health Sciences, Chinese University of Hong Kong Shenzhen (CUHK-SZ), Shenzhen, PR China

  14. Apr 2019, Seminar (Skype), School of Pharmacy, University College London, UK

  15. Apr 2019, Invited presentation. Micius Forum, School of Life Sciences, University of Science and Technology of China (USTC), Hefei, PR China

  16. Mar 2019, Invited presentation. Studying RNA mechanical unfolding dynamics using optical tweezers and targeting RNA structures with chemically modified dsRNA-binding PNAs. 1st Singapore-Paris Chemical Biology Workshop, Singapore

  17. Jan 2019, Seminar. Targeting RNA structures with chemically modified double-stranded RNA-binding PNAs. University of Hong Kong

  18. Dec 2018, Invited presentation. RNA folding and therapeutic targeting. Symposium of Chemical sensing, bio-imaging and chemical biology, 10th Singapore International Chemistry Conference, Singapore

  19. Sep 2018, Invited presentation. Single-molecule mechanical (un)folding of RNA: Unravelling mRNA structure’s role in translational regulation. East Asia Single-Molecule Symposium, The 56th Annual Meeting of The Biophysical Society of Japan, Okayama University, Japan

  20. Jul 2018, Keynote presentation. RNA folding and therapeutic targeting. The 5th National Conference on Biophysical Chemistry (NCBPC5), Shanxi University, PR China

  21. Jul 2018, Contributed presentation. Single-molecule mechanical (un)folding of RNA: Unravelling mRNA structure’s role in translational regulation. 8th World Congress of Biomechanics, Dublin, Ireland

  22. Feb 2018, Contributed presentation. Targeting double-stranded RNA structures by a peptide nucleic acids platform. Workshop on Healthcare and Biotechnology (jointly organized by Bioprocessing Technology Institute (BTI), A*STAR, Singapore and Sungkyunkwan University (SKKU), Republic of Korea), Singapore

  23. Jan 2018, Invited presentation. The 9th School of Basic Medical Sciences Annual Meeting, Zhejiang University, Hangzhou, PR China (2017)

  24. Nov 2017, Contributed presentation. A peptide nucleic acids platform for developing RNA structure-targeting biological tools and therapeutics. Aptamer Meeting, Hefei, PR China

  25. Oct 2017, Invited presentation. Targeting double-stranded RNA structures by chemically modified PNAs. RNA Biology Symposium, Singapore

  26. Sep 2017, Seminar. Targeting double-stranded RNA structures by a peptide nucleic acids platform. The Institute of Scientific and Industrial Research, Osaka University, Japan

  27. Sep 2017, Contributed presentation. Targeting double-stranded RNA structures by a peptide nucleic acids platform. The 1st Joint Workshop of Nanyang Technological University and Osaka University on Fundamental Science, Osaka University, Japan

  28. May 2017, Contributed presentation. Targeting double-stranded RNA structures by a peptide nucleic acids platform. The 7th International Conference on Nucleic Acid-Protein Chemical and Structural Biology, Chengdu, Sichuan province, PR China

  29. Apr 2017, Seminar. Targeting double-stranded RNA structures by a peptide nucleic acids platform. School of Life Science and Technology, Xi’an Jiaotong University, PR China

  30. Dec 2016, Contributed presentation. Developing RNA duplex-binding peptide nucleic acids for biotechnological applications. The 14th International Symposium for Chinese Organic Chemists (ISCOC), Singapore

  31. Nov 2016, Contributed presentation. Developing RNA duplex-binding peptide nucleic acids for biotechnological applications. The 2nd NTU-ICES (A*STAR) Joint Science Workshop, Singapore

  32. Jul 2016, Seminar. Developing RNA duplex-binding peptide nucleic acids for biotechnological applications. Institute of Advanced Energy, Kyoto University, Japan

  33. Jun 2016, Seminar. Developing RNA duplex-binding peptide nucleic acids for biotechnological applications. School of Life Sciences, Anhui Medical University, Hefei, PR China

  34. Jun 2016, Contributed presentation. Developing RNA duplex-binding peptide nucleic acids for biotechnological applications. The 4th National Conference on Biophysical Chemistry (NCBPC4), Hefei, PR China

  35. May 2016, Contributed presentation. Developing RNA duplex-binding peptide nucleic acids for biotechnological applications. The 6th International Conference on Nucleic Acid-Protein Chemical and Structural Biology for Drug Discovery, Chengdu, Sichuan province, PR China

  36. Nov 2015, Contributed presentation. Probing and targeting RNA structures by triplex formation. BIT’s 6th World Gene Convention-2015, chair/speaker in “RNA Biology, Nucleic Acids, Structural and Functional Genomics”, Qingdao, PR China

  37. Dec 2014, Invited presentation. Probing and targeting RNA structures by triplex formation. NITHM & CBC/SPMS-sponsored Workshop: “Cutting Edge Discovery in Chemical Biology for Future Biochemical Sciences”, SPMS, NTU, Singapore

  38. Nov 2014, Contributed presentation. Targeting RNA structures by triplex formation. BIT & SeNA-sponsored international nucleic acid conference: “RNA Biology and Nucleic Acid Chemical & Structural Biology”, Haikou, PR China

  39. Sep 2014, Invited presentation. Targeting RNA structures by triplex formation. Enabling Genomic Technologies and Screening Asia, SELECTBIO conference, Biopolis, Singapore

  40. Jul 2014, Contributed presentation. Targeting RNA structures by triplex formation. The 3rd National Conference on Biophysical Chemistry (NCBPC3), Qingdao, PR China

  41. Dec 2011, Contributed presentation. Force and fluorescence spectroscopy studies of RNA and RNA-protein complex. The Third Asian Spectroscopy Conference, Xiamen University, Xiamen, PR China

  42. Sep 2010, Seminar. Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of –1 ribosomal frameshifting. Department of Chemistry, National University of Singapore, Singapore

  43. Apr 2009, Seminar. Triplex structures in an RNA pseudoknot enhance mechanical stability and increase efficiency of –1 ribosomal frameshifting. RNA Club, Center for Molecular Biology of RNA, University of California, Santa Cruz, USA

  44. Jan 2009, Seminar. Base triples in RNA pseudoknots modulate mechanical stability and –1 ribosomal frameshifting efficiency. Department of Pharmaceutical Sciences, University of Nebraska Medical Center, USA

  45. Aug 2006, Contributed presentation. Mechanical manipulation of a pseudoknot from human telomerase RNA. Turner Symposium, University of Rochester, USA

  46. Nov 2005, Seminar. Expanded sequence dependence improves prediction of RNA internal loop stability and NMR reveals molecular recognition interactions accounting for stability, structure, and dynamics. RNA Structure and Function Cluster of University of Rochester, USA

  47. Sep 2004, Seminar. Thermodynamics and NMR of 3 × 3 internal loops in RNA. Biological Chemistry Cluster, University of Rochester, USA

 

A 2001 picture
Turner Symposium (2006)
Tinoco Symposium (2010)

http://sites.google.com/site/rnachen2/

 

 

 

 

 

 

 

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